The problem New FDA Approved Weight Loss: Drug Zepbound, a Weg solves

The US Food and Drug Administration (FDA) has granted approval to Zepbound, a weekly injectable medication designed to combat obesity. This groundbreaking treatment utilises tirzepatide, a key component also found in Manjaro, a diabetes medication.

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In a randomised-controlled trial published in the New England Journal of Medicine, patients who received the highest dose of Zepbound achieved a remarkable 21% reduction in total body weight. This promising development could bring hope to the estimated 1 billion individuals worldwide and 100 million Americans struggling with obesity.

Zepbound works by mimicking two natural hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). GLP-1 stimulates the pancreas to regulate blood sugar levels, while also delaying gastric emptying and suppressing hunger centres in the brain. GIP, on the other hand, reduces appetite by acting on brain receptors.

The FDA's approval of Zepbound may also have far-reaching implications for public health. The widespread demand for weight loss treatments creates an opportunity for compounding, a practice that involves mixing or altering drug ingredients. The popularity of Ozempic, a GLP-1 medication initially approved for diabetes but often prescribed off-label for weight loss, led to reports of unsafe and ineffective compounded versions. As demand for Zepbound grows, it remains to be seen whether compounding will become a concern.

Challenges I ran into

Xenical (Orlistat)
Xenical, a lipase inhibitor, helps individuals lose weight and maintain weight loss. When taken, no more than 30% of daily calories should come from fat. With its unique mechanism, Xenical is ideal for those who consume high-fat foods.

Alli (Orlistat)
Alli, an over-the-counter version of Xenical, contains the same active ingredient orlistat. It reduces fat absorption in the gut and is suitable for adults 18 and older. Alli tends to be better tolerated due to its lower dose.

Contrave (Bupropion-Naltrexone)
Contrave, a combination medication, works by stimulating the brain to regulate appetite. It is used in conjunction with a low-calorie diet and exercise. In clinical trials, participants who took Contrave lost more weight than those on a placebo.

Saxenda (Liraglutide)
Saxenda, a GLP-1 receptor agonist, stimulates the brain to regulate appetite. It is injected subcutaneously once daily and can be used in children ages 12 and older with obesity.

Qsymia (Phentermine-Topiramate)
Qsymia, a combination medication, works by reducing appetite. It is used in adults and children 12 and older with obesity. In clinical trials, participants who took Qsymia lost more weight than those on a placebo.